Nara Multidisciplinary approach for well-being

Speaker

Brian Patrick Head

Department of Anesthesia

University of California, San Diego

EDUCATION / TRAINING

1990-1994 Georgetown University, B.A.
Major: American Government; Minor: Theology 		Washington, DC
1996-2001 University of San Diego, M.S.
M.S. Marine Science Graduate Program
Department of Marine Sciences, Advisor: N. Chin Lai, Ph.D. 		San Diego, CA
2000-2005 University of California, San Diego (Doctorate) Molecular Pathology Graduate Program Department of Pharmacology, Advisor: Paul A. Insel, M.D. La Jolla, CA
2006-2009 University of California, San Diego – VA San Diego Healthcare System Post-doctoral fellowship
Department of Anesthesiology, Mentor: Piyush M. Patel, M.D. 		San Diego, CA
2009-2012 University of California, San Diego
Assistant Research Scientist
Department of Anesthesiology 		San Diego, CA
2009-2012 VA San Diego Healthcare System
Career Development Awardee, Research Scientist
Research Service, Mentor: Gerhard Schulteis, Ph.D 		San Diego, CA
2009-Present VA San Diego Healthcare System
Principal Investigator, Research Scientist
Research Service 		San Diego, CA
2012-2015 University of California, San Diego
Assistant Professor Department of Anesthesiology 		San Diego, CA
2015-Present University of California, San Diego
Associate Professor Department of Anesthesiology 		San Diego, CA

PROFESSIONAL EXPERIENCE

Marine Science Instructor.SEACAMP San Diego, San Diego, CA (1997-1998).
Education instructor on fish, invertebrate and marine mammal biology lectures and laboratories as well as laboratories covering processes of oceanography and water chemistry to students in grades 5 through 12. Provided instruction and supervision over marine recreational activities such as open water snorkeling and SCUBA diving trips to the local Channel Islands (i.e., Coronado, San Clemente, and Catalina Islands) near southern California.

Thesis Research.Marine science Graduate Program, University of San Diego (1996-2001). Mentor: N. Chin Lai, PhD. The California horn shark (Heterodontus francisci), instrumented with a pericardial catheter and a ventral-aortic flow probe, was studied to determine the effect of complete pericardial chamber evacuation on the time course of restitution of pericardial fluid-volume and pressure, and the effects of both fluid removal and its restitution on cardiac output. Pericardial pressure-volume relationships, determined by incremental infusion of small volumes of elasmobranch saline into the pericardium, confirm previous findings that the operating pericardial pressure in the horn shark is at or near ambient pressure and that both pericardial fluid volume and cardiac stroke volume influence horn shark pericardial pressure.

Laboratory Technician. Veterinary Medical Research Foundation-Veterans Administration Hospital, La Jolla, CA (1998-2000). Performed major and minor surgeries and conducted in vivo cardiovascular experiments on pigs and rodents measuring hemodynamics (i.e., heart rate, contractility, and left atrial, aortic, and pulmonary arterial pressures) and echocardiography to assess left ventricular contractility in normal and diseased models. Assisted in delivery of adenoviral vector (Adv-VEGF and Adv-FGF 4) to induce angiogenesis in pigs with myocardial ischemia and to increase adenylyl cyclase expression (Adv-AC6) in order to raise cAMP production and cardiac contractility in normal pigs. Assisted with physiological data acquisition and analysis and maintenance of experimental records. The goal of the study was to determine whether global left ventricular (LV) function could be increased by intracoronary delivery of an adenovirus expressing AC6.

Dissertation Research. Molecular Pathology Graduate Program and Department of Pharmacology, University of California, San Diego (2000-2005). Mentor: Paul A. Insel, MD. Investigating the compartmentation of G protein-coupled receptor signaling components to caveolae (i.e., sarcolemmal microdomains) and how caveolar-cytoskeletal (i.e., tubulin and actin) interactions regulate cAMP production in adult cardiac myocytes.

Biology Laboratory Instructor. Biology Department, University of San Diego (Fall, 2006). Instructor for Introduction to Cellular Processes Laboratory (225L). The course provides an introduction to the concepts of structure and function in biological systems at the molecular and cellular level. The topics of cell structure and function, biological macromolecules, respiration, photosynthesis, molecular biology, and selected areas of physiology are covered with emphasis on regulatory mechanisms.

Postdoctoral Research. Department of Anesthesia (2006-2009). 1) Investigating the role of caveolin-associated microdomains in regulating N-methyl-D-aspartate receptor (NMDAR) signaling in both an in vivo and in vitro model of neuronal preconditioning. 2) Studying the mechanisms of anesthesia induced neurotoxicity in developing neurons from the central nervous system.

HONORS AND AWARDS

  1. Academic honor roll Fall and Spring semesters of my junior year at Georgetown University, Washington, D.C. 1992-1993.
  2. The 23rd International Symposium on Cerebral Blood Flow, Metabolism, & Function (Brain 2007)-Young Bursary Winner ($1,000).
  3. Society for Neuroscience San Diego Chapter (2009) – 1st Prize Poster Presentation.
  4. 2012 PECASE Honor (Presidential Early Career Award for Scientists and Engineers) – Department of Veterans Affairs, Ceremony was held at the White House, April 2014 ($75,000).

PATENT

  1. U.S. Patent No. 8,969,077 B2: Neuronal specific targeting of caveolin expression to restore synaptic signaling and improve cognitive function in the neurodegenerative brain and motor function in spinal cord Co-Inventors: Piyush M. Patel, Hemal H. Patel, and David M. Roth. (March 3, 2015)

RESEARCH GRANTS

  1. NIH Pharmacology Training Grant (pre-doctoral) 2001-2005
  2. RAG-Research Advisory Group Fellowship (post-doctoral) 2005-2008
  3. Career Development Award-2, Veteran Affairs San Diego Healthcare System, 2009-2012. Title: Aged related loss of caveolin and synaptic signaling in the brain. $158,000/year for 3 years. The central hypothesis is that caveolin is necessary for synaptic mediated signaling and neuroprotection, and that loss of caveolin-associated microdomains with age leads to altered synaptic signaling, loss of neuroprotection, resulting in neurocognitive dysfunction. Caveolin therefore plays a key regulatory role in organizing plasmalemmal synaptic signaling neuroprotection.
  4. American Physiological Society – Central Nervous System New Investigator Award (2011)
  5. 1R01NS073653-01A1 (PI: Head, B) 12/01/2011 – 12/01/2015 National Institute of Neurological Disorders and Stroke “Neuronal-targeted caveolin-1 as a therapy for traumatic brain injury”. The central hypothesis of this proposal is that neuron-targeted caveolin-1 initiates lipid raft formation and enhances pro-survival signaling pathways, thereby promoting neuronal survival, axonal sprouting and dendritic growth. This leads to a substantial reduction in neuronal injury and improved motor and cognitive function post-traumatic brain injury. Role: Principal Investigator
  6. 1I01BX001225-01A2 (PI: Head, B) 4/01/2012 – 4/01/2015 Veterans Affairs Merit. The central hypothesis is that caveolin is necessary for enhancing membrane/lipid raft formation, growth cone advancement, and neuritic extension. Loss of caveolin-associated microdomains with age leads to altered synaptic signaling, loss of neuroprotection, resulting in neurocognitive dysfunction. Caveolin therefore plays a key regulatory role in organizing plasmalemmal synpatic signaling components, promoting membrane/lipid raft formation, and enhancing neuronal growth in the injured and neurodegenerative brain. Role: Principal Investigator
  7. AZ140064 (MPI: Head, B & Shah, S) 07/01/2015 – 06/30/2018 Department of Defense. “Mouse and Human Models for Investigating Influences of Tau on Progression of Alzheimer's Disease Following Traumatic Neuronal Injury”. This multi-disciplinary study uses a human induced pluripotent stem cell traumatic injury model and an in vivo mouse traumatic brain injury model to examine the role of the cytoskeleton-associated protein tau in the progression of markers related to Alzheimer’s Disease. Role: Principal Investigator
  8. 1I01BX003671-01A1 (PI: Head, B) 04/01/2017- 03/31/2021 “Caveolin-mediated neuronal signaling in differentiated adult human neuronal stem cells and the aging brain”. The grant proposal focuses on the mechanism through which neuron-targeted caveolin-1 enhances neuroplasticity and improves learning and memory in human iPSC-derived neurons and in a mouse model of Alzheimer’s disease.

PENDING RESEARCH GRANTS

NIH/NIA R01AG061739 (PI: Head, B; co-PI: Wagner, S) 09/01/2018-08/31/2023
“Impact of traumatic brain injury on the progression of Alzheimer’s disease and the therapeutic effects of gamma-secretase modulation”
The proposed research will assess the following: 1) TBI exacerbates AD progression, and 2) delivery of a small molecular gamma secretase modulator (GSM) at different time points post TBI will ameliorate the TBI-mediated AD progression. Both wild type and an AppNL-F/NL-F knock-in mutant mouse model will be used in the proposed studies.

NIH/NINDS R01 Renewal (PI: Head, B) 07/01/2015-06/30/2020
“Mechanisms of Neuron-Targeted Caveolin-1-Mediated Neuroplasticity After Injury”
The proposed research will attempt to use a novel approach, i.e., neuron-targeted overexpression of caveolin in combination with existing pharmacology interventions to enhance structural and functional neuroplasticity after stretch-induced injury in human iPSC derived neurons in vitro.

VA Merit I01BX003921 (PI: Head, B) 10/01/2017- 09/30/2021
“Neuron-targeted caveolin as a therapy for Amyotrophic Lateral Sclerosis”
The proposed research will attempt to use a novel approach, i.e., neuron-targeted overexpression of caveolin in combination with neurotrophin receptor agonism to restore alpha motor neuronal function and prolong survival in a hSOD1G93A model of ALS.

EXTERNAL PROFESSIONAL ACTIVITIES

Professional Society Memberships

  • Society for Neuroscience, 2006-Present
  • American Physiological Society, 2009-Present
  • American Society for Pharmacology and Experimental Therapeutics (ASPET) 2001-present
  • American Heart Association 2006-present

Ad Hoc Journal and Grant Reviewer for:

  • American Journal of Pathology
  • American Journal of Physiology: Cell Physiology
  • Anesthesiology
  • Annals of Neurology
  • BMC Research Notes
  • Brain Research
  • Cellular and Molecular Life Sciences
  • FEBS Journal
  • Frontiers in Medicine
  • Journal of Alzheimer’s Disease
  • Journal of Cerebral, Blood Flow, and Metabolism (JCBM)
  • Journal of Biological Chemistry (JCB)
  • Journal of Neurosurgical Anesthesiology (JNA)
  • International Journal of Molecular Sciences
  • Molecular and Cellular Biochemistry
  • Molecular and Cellular Endocrinology
  • Microvascular Research
  • Nature Materials (served as adjudicating referee)
  • Neurobiology of Aging
  • Neuromolecular Medicine
  • Neurorehabilitation and Neural Repair
  • Pharmacology, Biochemistry and Behavior
  • PLoS One
  • Proceedings of National Academy of Sciences (PNAS)
  • Grant reviewer for Alzheimer’s Association (2010-Present)
  • Poster Competition Judge for Western Anesthesia Residents Conference (WARC-2012)
  • Abstract Reviewer for American Society of Anesthesiologists (2012-Present)
  • Abstract Reviewer for Brain Conference (2013)
  • Grant Reviewer for the International Anesthesia Research Society (IARS), Chicago, IL (2013-Present)
  • Grant Reviewer for NINDS RFA-NS-13-14 “Pilot Projects on Sports-Related Brain and Spinal Cord Injury”, June/July 2013
  • American Heart Association, Cell Transport 1, (2014)

UNIVERSITY and COMMITTEE SERVICE

  • Member: Veterans Affairs San Diego Health Care Systems Institutional Animal Care and Use Committee (Jan. 2008-Present)
  • Member: Veterans Affairs San Diego Health Care Systems Subcommittee on Research Safety (Jan. 2009-2013)
  • Member: Veterans Affairs San Diego Health Care Systems Research and Development Committee (Jan. 2013-Present)
  • Lecturer: NEU 221: Neurobiology of Disease: Mechanisms of Neurodegeneration, University of California, San Diego (Jan. 2014-Present)
  • Lecturer: PGY4 Neuroscience Series (Psychiatry Residency 4th year, UCSD): Traumatic Brain Injury
  • Lecturer: 235 Human Physiology, San Diego City College (2015-Present)

SCIENTIFIC COMMUNITY SERVICE and INVITED LECTURES

  1. Oral Presentation: “Caveolar microdomains concentrate signal transduction of ß1-adrenergic receptors, but not ß2-adrenergic receptors in adult rat cardiac myocytes.” American Heart Association Oral and Poster presentation 2002. Chicago, IL.
  2. Biology Laboratory Instructor. Biology Department, University of San Diego (Fall, 2006). Instructor for Introduction to Cellular Processes Laboratory (225L).
  3. Oral Presentation: Experimental Biology, American Physiological Society 2006. “Cytoskeletal components regulate expression of caveolae, caveolin phosphorylation and cAMP production.” San Francisco, CA.
  4. Gordon Research Conference, Summer 2006 (Mount Holyoke College, Mt. Holyoke, MA), Macromolecular Organization & Cell Function, poster presentation “Cytoskeletal components regulate expression of caveolae, caveolin phosphorylation and cAMP production.”
  5. Judge for Anesthesia Resident Poster competition at WARC (Western Anesthesia Residence Conference), Santa Monica, CA 2012
  6. Chair and Speaker, April 2013 (Boston, MA), Experimental Biology 2013, American Physiological Society: Central Nervous System “Neuronal Membrane/Lipid Rafts: Organizers of Membrane Signaling, Neuritic Growth and Guidance”
  7. Oral Presentation: Department of Veterans Affairs Office of Research Development for the PECASE honor, April 2014 (Washington, D.C.) “Neuron-targeted caveolin-1 enhances hippocampal plasticity and function”
  8. Oral Presentation: Veterans Affairs San Diego Healthcare System (VASDHS) Research Week, May 2014 (San Diego, CA) “Gene therapy for enhancing brain function in the aging brain”
  9. Oral Presentation: Department of Psychiatry, UCSD, Translational Methamphetamine AIDS Research Center (TMARC), July, 2014 (San Diego, CA) “Gene therapy for enhancing brain function in the aging brain”
  10. Oral Presentation: Department of Orthopaedics, UCSD, Orthopaedic Surgery Research Conference, October 2014 (La Jolla, CA) “Gene therapy for enhancing brain function in the aging brain”
  11. Visiting Professor at the Columbia University Medical Center on November 19, 2014 to present his work entitled “Neuron-targeted Caveolin-1 Enhances Hippocampal Plasticity and Function” to the Department of Anesthesia.
  12. Chair and Speaker, April 2015 (Edinburgh, UK) The Physiological Society 2015, Ageing and Degeneration Symposium “Membrane/lipid rafts: Age-associated changes in membrane biology and function”
  13. Oral Presentation: Tiantan International Neurosurgical Anesthesia Symposium (TINAS), Beijing Tiantan Hospital Capital Medical University and University of California San Francisco, Beijing, China, May 2015 “Neuro-targeted Caveolin-1 enhances hippocampal plasticity and function”
  14. Visiting Professor: Department of Anatomy and Cell Biology, University of Illinois Chicago, June 2015 “Membrane/lipid rafts, Caveolin-1, and Neuroplasticity in the Aged Brain”
  15. Visiting Professor: St. Anne’s University Hospital/The International Clinical Research Center (ICRC), Brno, Czech Republic, April 2016, “Caveolin-1 and Neuroplasticity: Therapeutic Implications for Neuroregeneration”
  16. Visiting Professor: University of Leicester, Department of Neuroscience, Psychology, and Behavior, April 2017 (Leicester, U.K.), “Neuron-targeted Caveolin-1 promotes functional neuroplasticity”
  17. Visiting Professor: RIC-Shirley Ryan AbilityLab, May 2017 (Chicago, IL), “Neuron-targeted Caveolin-1 regulates membrane signaling and functional neuroplasticity”
  18. Invited Speaker, August 2017 (San Diego, CA), Ono Pharmaceuticals, “SynCav1 Therapy for CNS Disorders”
  19. Invited Lecturer, November 2017 (San Diego, CA), UC San Diego Inside Innovation, Office of Innovation and Commercialization, “SynCav1 Therapy for CNS Disorders”
  20. Visiting Professor and Faculty Recruitment Interview: Department of Anatomy and Cell Biology, University of Illinois Chicago, November 2017 “SynCav1 Gene Therapy for CNS Disorders”

UNIVERSITY SERVICE

Postdoctoral Fellows Mentored

  1. Takaakira Yokoyama, UCSD Postdoctoral Fellow, 2006-2008 (Research Advisor); Currently Assistant Professor, Department of Neurosurgery, Yokohama University, Japan
  2. Melissa Reichelt, UCSD Postdoctoral Fellow, 2008-2009 (Research Advisor), Currently Postdoctoral Fellow in Melbourne
  3. Byeong Jo Chun, UCSD Postdoctoral Fellow, 2008-2010 (Research Advisor), Currently Associate Professor, South Korea
  4. Mathivadhani Paneerselvam, UCSD Postdoctoral Fellow, 2007-2012, Research Advisor
  5. Yoshitaka Kawaraguchi, UCSD Postdoctoral Fellow, 2008-2011, Research Advisor
  6. Heidi Fridolfsson, UCSD Undergraduate Student, 2004-2005 (Research Advisor); UCSD Postdoctoral Fellow, 2010-2014, Research Advisor
  7. Jan Schilling, Postdoctoral Fellow, 2010-Present, Research Advisor
  8. Sunaho Okada, UCSD Postdoctoral Fellow, 2010-2012, Research Advisor
  9. Jiawan Wang, MD, Visiting Fellow, 2011-2013, Capital Medical University, Beijing, China
  10. Adam Kassan, PhD, UCSD Postdoctoral Fellow, 2012-2017
  11. Weihua (Alexandra) Cui, MD, Visiting Fellow; 2012-2014, Pediatric Anesthesiologist Beijing Children’s Hospital, Beijing, China
  12. Supriyo Ray, PhD, UCSD Postdoctoral Fellow, 2013-2017
  13. *Junji Egawa, MD, Visiting Fellow; 2013-2015, Anesthesiologist, Nara Medical University, Nara, Japan
  14. Minyu Jian, MD, Visiting Fellow; 2014, Neuroanesthesiologist Beijing Tiantan Hospital, Beijing, China
  15. *Atsushi Sawada, MD, Visiting Fellow; 2015-2016, Anesthesiologist, Sapporo Medical University, Sapporo, Japan
  16. Shanshan Wang, MD, Visiting Fellow; 2015-Present, Neuroanesthesiologist Beijing Tiantan Hospital, Beijing, China
  17. Jonathan Okerblom, UCSD Postdoctoral Fellow, 2017-Present, co-mentor

Graduate Students Mentored

  1. Yousuke Horikawa (2005-2009), MSTP Program UCSD – Research Advisor; Currently completing medical training portion of MSTP
  2. Igor Guryev (2010-2011), Masters in Science Graduate Program UCSD, Co-advisor Dr. Head
  3. Anna Grove (2011-2012), Medical Student, UCSD basic science researcher; Currently completing medical school at UCSD
  4. Rosalie Schnoor (2012), Visiting Medical Student, Holland
  5. Kristofer Haushalter (2010-Present), Biomedical Graduate Program, UCSD
  6. Suzanne Rorhback (2011-2014), Biomedical Science Graduate Program, UCSD
  7. Anna Busija (2011-Present), Biomedical Science Graduate Program, UCSD
  8. Marriane Catanho Halloran (2012-2018), Bioengineering Graduate Program, UCSD, Committee Member.
  9. #Edmund Posadas (2015), Medical Student, UCSD, Awarded Research Fellowship from NIH Summer Research Training Grant
  10. #Jesse Wackerbarth (2015), Medical Student, UCSD, Awarded Research Fellowship from NIH Summer Research Training Grant
  11. Melissa H. Galinator (2015-2017), Neurosciences Doctoral Student, UCSD, Committee Member
  12. Jeff Bernstein (2017), Medical Student, UCSD, MSTAR (Medical Student Training in Aging Research) UCSD Summer Research Training

Undergraduate Research Students Mentored

  1. Michelle Jennings (2005-2007); Currently Case Western University MD, PhD Graduate Program
  2. Blake Chin-Lee (2005-2007); Currently Penn State University Medical School
  3. Stephanie Cipta (2005-2008); Currently Rosalind Franklin University of Medicine and Science
  4. Ana Moreno (2005, 2007-2009); NY Medical College (status: UCSD Anesthesia Resident)
  5. Mike Kidd (2005-2009); Currently University of Tennessee Memphis Doctoral Graduate Program
  6. Trisha Mejia (2005-2007); Currently San Diego State University Masters in Public Health Graduate Program
  7. Jacqueline A Bonds (2009-2011); Currently University of Illinois Chicago Doctoral Graduate Program
  8. Sarah E Kellerhals (2010-2013); Currently University of Arizona Medical School
  9. April Voong (2011-2012)
  10. Joseph Cameron Finley (2011-2013)
  11. Michael Migita (2011-2014)
  12. Selma Garcia (2012-2016)
  13. Edmund Posadas (2013-2014)

Other Programs

  1. Anton Cujec, High School Student, High Tech High, San Diego, January 2014, Research Advisor
  2. Meilynn Shi, High School Student, Westview High School, Summer (2013, 2014), Research Advisor
  3. Mentor, Medical Scientist Training Program Summer Undergraduate Research Fellowship Program for Underrepresented Minorities (2006-Ana Moreno; 2007-Tony Baltazar; 2008-Michelle Saldana and Valarie Soued; 2009-Christina Ruiz; 2010-Marikah Davin; 2011-Soumaya Bader and Laura Padilla).
  4. Mentor, California Alliance for Minority Participation in Science, Engineering, and Mathematics (2008-2010-Michelle Saldana)

Anesthesia Residents Mentored

  1. Brian Lemkuil, MD, UCSD Anesthesia Resident Research Fellow, 2009 (Research Advisor); Currently Assistant professor of clinical anesthesia, UCSD
  2. *Matt Pearn, MD, UCSD Anesthesia Resident Research Fellow, 2009-2010 (Research Advisor); Currently Postdoctoral Fellow, Dr. Mobley Laboratory, UCSD
  3. Hetal Hosalkar, MD, UCSD Anesthesia Research Fellow, 2009-2010 (Research Advisor); Currently Sharp Healthcare San Diego Area
  4. Veena Salgar, MD, UCSD Anesthesia Research Fellow, 2010-2012 (Research Advisor); Currently Neuroscience Fellowship, Dr. Head’s Laboratory, VA/UCSD
  5. *Creed Stary, PhD, MD, UCSD Anesthesia Resident Research Fellow, 2011-2012 (Research Advisor)
  6. Brett Cronin, MD, UCSD Anesthesia Resident Research Fellow, 2012-2013 (Research Advisor)
  7. Anna Shapiro, MD, UCSD Anesthesia Resident Research Fellow, 2014-2015 (Research Advisor)
  8. Rishi Parikh, MD, UCSD Anesthesia Resident Research Fellow, 2015 (Research Advisor)
  9. *Benjamin Illum, MD, UCSD Anesthesia Resident Research Fellow, 2016 (Research Advisor)
  10. Kim (Ying) Zhou, MD, UCSD Anesthesia Resident Research Fellow, 2017 (Research Advisor)
  • *Dr. Pearn was awarded 1st Place CSA Resident Research Award, 1st Place ASA Resident Essay Contest for Basic Science Studies, and was awarded SNACC John D. Michenfelder New Investigator Award for the work conducted during his research rotation under Dr. Head’s mentorship.
  • *Dr. Stary was awarded 1st Place WARC Resident Research Award (2012).
  • *Dr. Egawa was awarded the SNACC John D. Michenfelder New Investigator Award (2014) for the work conducted during his research rotation under Dr. Head’s mentorship
  • *Dr. Illum was awarded 1st place at the International Research Society Resident Research Award (2016) and 1st Place WARC Resident Research Award (2016)
  • *Dr. Sawada was the SNACC Resident Research Travel Award (2016)
  • #Edmund Posadas was awarded Research Fellowship from NIH Summer Research Training Grant (2015)
  • #Jesse Wackerbarth was awarded Research Fellowship from NIH Summer Research Training Grant (2015)

PUBLICATIONS

Total citations as of 8/30/17: 2852
h-Index: 29
i10-index: 34

  1. Lai NC, Roth DM, Gao MH, Fine S, Head BP, Zhu J, McKirnan MD, Kwong C, Dalton N, Urasawa K, Roth DA, Hammond MD. Intracoronary delivery of adenovirus encoding adenylyl cyclase VI increases left ventricular function and cAMP-generating capacity. Circulation 102:2396-2401, 2000.
  2. Head BP, Graham JB, Shabetai R, Lai NC. Regulation of cardiac function in the horn shark by changes in pericardial fluid volume mediated through the pericardioperitoneal canal. Fish Physiol Biochem. 24:141-148, 2001.
  3. Ostrom RS, Liu X, Head BP, Gregorian C, Seasholtz TM, Insel PA. Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: expression in caveolin-rich and noncaveolin domains. Mol Pharmacol. 62:983-9, 2002.
  4. Head BP, Patel HH, Lai NC, Niesman IR, Roth DM, Farquhar MG, and Insel PA. G-protein coupled receptor signaling components localize in both sarcolemmal and intracellular Caveolin-3-associated microdomains in adult rat cardiac myocytes. J Biol Chem. 280:31036-31044, 2005.
  5. Insel PA, Head BP, Ostrom RS, Patel HH, Swaney JS, Tang C-M, Roth DM. Caveolae and lipid rafts: G-protein-coupled receptor signaling microdomains in cardiac myocytes. Annals NY Acad Sci. 1047:166-172, 2005.
  6. Insel PA, Head BP, Patel HH, Roth DM, Niesman IR, Farquhar MG, and Bundey R. Compartmentation of G-protein-coupled receptors and their signaling components in lipid rafts and caveolae. Biochem Soc Transact. 33:1131-1134, 2005.
  7. Patel HH, Head BP, Petersen HN, Niesman IR, Feramisco JR, Farquhar MG, Gross GJ, Insel PA, and Roth DM. Protection of adult rat cardiomyocytes from ischemic cell death: role of caveolar microdomains and opioid receptors. Am J Physiol: Heart Circ Physiol. 291:H344-H350, 2006.
  8. Tsutsumi Y, Patel HH, Lai NC, Takahashi T, Head BP, Roth DM. Isoflurane produces sustained cardiac protection after ischemia-reperfusion injury in mice. Anesthesiology 104: 495-502, 2006.
  9. Swaney JS, Patel HH, Head BP, Roth DM, Insel PA. Focal adhesions in (myo)fibroblasts scaffold adenylyl cyclase with phyosphorylated caveolin. J Biol Chem. 281:17173-17179, 2006.
  10. Head BP, Patel HH, Roth DM, Murray F, Swaney JS, Niesman IR, Farquhar MG, and Insel PA. Microtubules and actin microfilaments regulate lipid raft/caveolae localization of adenylyl cyclase signaling components. J Biol Chem. 281:26391-26399, 2006.
  11. Head BP and Insel PA. Do caveolins regulate cells by actions outside of caveolae? Trends in Cell Biol. 17:51-57, 2007.
  12. Patel HH, Tsutsumi YM, Head BP, Niesman IR, Horikawa Y, Huang D, Moreno AL, Jennings M, Patel PM, Insel PA and Roth DM. Mechanisms of cardiac protection from ischemia/reperfusion injury: a role for caveolae and caveolin-1. FASEB J. 21:1565-74, 2007.
  13. Patel HH, Zhang S, Murray F, Suda RYS, Head BP, Swaney JS, Niesman IR, Schermuly RT, Pullamsetti S, Thistlethwaite PA, Miyanohara A, Farquhar MG, Yuan JXJ and Insel PA. Increased caveolin-1 and caveolae expression contribute to the pathophysiology of idiopathic pulmonary arterial hypertension. FASEB J. 21:2970, 2007.
  14. Head BP, Patel P. Anesthetics and brain protection. Curr Opin Anaesthesiol. 20:395-9, 2007.
  15. Head BP, Patel HH, Tsutsumi YM, Hu Y, Mejia T, Mora RC, Insel PA, Roth DM, Drummond J, and Patel PM. Caveolin-1 expression is essential for N-methyl-D-aspartate receptor-mediated Src and extracellular signal-regulated kinase 1/2 activation and protection of primary neurons from ischemic cell death. FASEB J. 22:828-40, 2008.
  16. Tsutsumi YM, Horikawa YT, Jennings MM, Kidd MW, Niesman IR, Yokoyama U, Head BP, Hagiwara Y, Ishikawa Y, Miyanohara A, Patel PM, Insel PA, Patel HH, Roth DM. Cardiac-specific overexpression of caveolin-3 induces endogenous cardiac protection by mimicking ischemic preconditioning. Circulation 118:1979-88, 2008. PMCID: PMC2676165
  17. Head BP, Patel HH, Niesman IR, Drummond JC, Roth DM, Patel PM. Inhibition of p75 neurotrophin receptor attenuates isoflurane-mediated neuronal apoptosis in the neonatal central nervous system. Anesthesiology 110:813-25, 2009. PMCID: PMC2767332
  18. Tsutsumi YM, Kawaraguchi Y, Horikawa YT, Niesman IR, Kidd MW, Chin-Lee B, Head BP, Patel PM, Roth DM, Patel HH. Role of caveolin-3 and glucose transporter-4 in isoflurane-induced delayed cardiac protection. Anesthesiology 112:1136-45, 2010. PMCID: PMC2860616
  19. Drummond JC, Head BP, Patel PM. Statins might contribute to postoperative delirium. Anesthesiology 113:500-1, 2010.
  20. Panneerselvam M, Tsustumi YM, Bonds JA, Horikawa Y, Saldana M, Dalton ND, Head BP, Patel PM, Roth DM, Patel HH. Dark chocolate receptors: epicatechin-induced cardiac protection is dependent on {delta} opioid receptor stimulation. Am J Physiol: Heart Circ Physiol. 2010 Nov, 299(5): H1604-9.
  21. Head BP, Peart JN, Panneerselvam M, Yokoyama T, Pearn ML, Niesman IR, Bonds JA, Schilling JM, Miyanohara A, Headrick J, Ali SS, Roth DM, Patel PM, Patel HH. Loss of Caveolin-1 accelerates neurodegeneration and aging. PLoS One. 2010 Dec 23;5(12):e15697.
  22. Lemkuil BP*, Head BP*, Pearn ML, Patel HH, Drummond JC, Patel PM. Isoflurane neurotoxicity is mediated by p75NTR-RhoA activation and actin de-polymerization. Anesthesiology. 114(1): 49-57, 2011. *Authors contributed equally.
  23. Panneerselvam M, Patel PM, Roth DM, Kidd MW, Chin-Lee B, Head BP, Niesman IR, Inoue S, Patel HH, Davis DP. Role of decoy molecules in neuronal ischemic preconditioning. Life Sci. 88(15-16): 670-4, 2011.
  24. Horikawa YT, Panneerselvam M, Kawaraguchi Y, Tsutsumi YM, Ali SS, Balijepalli RC, Murray F, Head BP, Niesman IR, Rieg T, Vallon V, Insel PA, Patel HH, Roth DM. Cardiac-specific overexpression of cavoelin-3 attenuates cardiac hypertrophy and increases natriuretic Peptide expression and signaling. J Am Coll Cardiol. 57(22): 2273-83, 2011.
  25. Head BP, Hu Y, Finley JC, Saldana MD, Bonds JA, Miyanohara A, Niesman IR, Ali SS, Murray F, Insel PA, Roth DM, Patel HH, Patel PM. Neuron-targeted caveolin-1 enhances signaling and promotes arborization of primary neurons. J Biol Chem. 286(38): 33310-21, 2011.
  26. Kawaraguchi Y, Horikawa YT, Murphy AN, Murray F, Miyanohara A, Ali SS, Head BP, Patel PM, Roth DM, Patel HH. Volatile anesthetics protect cancer cells against tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis via caveolins. Anesthesiology. 115(3): 499-508, 2011.
  27. Krajewska M, You Z, Rong J, Kress C, Huang X, Yang J, Kyoda T, Leyva R, Banares S, Hu Y, Sze CH, Whalen MJ, Salmena L, Hakem R, Head BP, Reed JC, Krajewski S. Neuronal deletion of caspase 8 protects against brain injury in mouse models of controlled cortical impact and kainic acid-induced excitotoxicity. PLoS One. 2011;6(9):e24341.
  28. Pearn ML, Hu Y, Niesman IR, Patel HH, Drummond JC, Roth DM, Akassoglou K, Patel PM, Head BP. Propofol neurotoxicity is mediated by p75 neurotrophin receptor activation. Anesthesiology. 116(2): 352-361, 2012.
  29. Fridolfsson HN, Kawaraguchi Y, Ali SS, Panneerselvam M, Niesman IR, Finley JC, Kellerhals SE, Migita MY, Okada H, Moreno AL, Jennings M, Kidd MW, Bonds JA, Balijepalli RC, Ross RS, Patel PM, Miyanohara A, Chen Q, Lesnefsky EJ, Head BP, Roth DM, Insel PA, Patel HH. Mitochondria-localized caveolin in adaptation to cellular stress and injury. FASEB J. 26(11):4637-49, 2012.
  30. Stary CM, Tsutsumi YM, Patel PM, Head BP, Patel HH, Roth DM. Caveolins: targeting pro-survival signaling in the heart and brain. Front Physiol. 3:393, 2012.
  31. Panneerselvam M, Ali SS, Finley JC, Kellerhals SE, Migita MY, Head BP, Patel PM, Roth DM, Patel HH. Epicatechin regulation of mitochondrial structure and function is opioid receptor dependent. Mol Nutr Food Res. 57(6):1007-14, 2013.
  32. Niesman IR, Zemke N, Fridolfsson HN, Haushalter KJ, Levy K, Grove A, Schnoor R, Finley JC, Patel PM, Roth DM, Head BP, Patel HH. Caveolin isoform switching as a molecular, structural, and metabolic regulator of microglia. Mol Cell Neurosci. 56C:283-297, 2013.
  33. Head BP, Patel HH, Insel PA. Interaction of membrane/lipid rafts with cytoskeleton: Impact on signaling and function: Membrane/Lipid Rafts, Mediators of Cytoskeletal Arrangement and Cell Signaling. Biochem Biophys Acta. 25: 145-159, 2013.
  34. Niesman IR, Schilling JM, Shapiro LA, Bonds JA, Kleschevnikov A, Cui W, Voong A, Krajewski S, Ali SS, Roth DM, Patel HH, Patel PM, Head BP. Traumatic brain injury enhances neuroinflammation and lesion volume in caveolin deficient mice. J Neuoinflammation. 11: 39, 2014.
  35. Schilling JM, Cui W, Godoy JC, Risbrough VB, Niesman IR, Roth DM, Patel PM, Drummond JC, Patel HH, Zemljic-Harpf AE, Head BP. Long-term atorvastatin treatment leads to alterations in behavior, cognition, and hippocampal biochemistry. Behav Brain Res, 267:6-11, 2014.
  36. Wang J, Schilling JM, Niesman IR, Headrick JP, Finley JC, Kwan E, Patel PM, Head BP, Roth DM, Yue Y, Patel HH. Cardioprotective trafficking of caveolin to mitochondria is Gi-protein dependent. Anesthesiology. 121:538-48, 2014. PMCID: PMC4219636
  37. Forati E, Sabouni A, Ray S, Head BP, Schoen C, Sievenpiper D. Neurotransmitter Specific, Cellular-Resolution Functional Brain Mapping Using Receptor Coated Nanoparticles: Assessment of the Possibility. PLoS One. 2015; 10(12):e0145852. PMID: 26717196; PMCID: PMC4696845.
  38. Egawa J, Pearn ML, Lemkuil BP, Patel PM, Head BP. Membrane/lipid Rafts and Neurobiology: Age-related changes in membrane lipids and loss of neuronal function. J Phys. 2016 594(16):4565-79. doi: 10.1113/JP270590. (Epub ahead of print)
  39. Mandyam, CD, Schilling JM, Cui W, Egawa J, Niesman IR, Kellerhals SE, Staples MC, Busija AR, Risbrough VB, Posadas E, Grogman GC, Chang JW, Roth DM, Patel PM, Patel HH, Head BP. Neuron-targeted caveolin-1 improves molecular signaling, plasticity and behavior dependent on the hippocampus in adult and aged mice. Biol. Psych. 81: 101-110, 2017.
  40. Pearn ML, Niesman IR, Egawa J, Sawada A, Almenar-Queralt A, Shah SB, Duckworth JL, Head BP. Pathophysiology associated with traumatic brain injury: current treatments and potential novel therapeutics. Cell Mol Neurobiol. 2016 (Epub ahead of print).
  41. Somkuwar SS, Fannon MJ, Head BP, Mandyam CD. Methamphetamine reduces expression of cavoelin-1 in the dorsal striatum: Implication for dysregulation of neuronal function. Neuroscience. 328: 147-56, 2016.
  42. Kassan A, Pham U, Nguyen Q, Reichelt ME, Cho E, Patel PM, Roth DM, Head BP, Patel HH. Caveolin-3 plays a critical role in autophagy after ischemia-reperfusion. Am J Physiol Cell Physiol. 311: C854-C865, 2016.
  43. Kassan A, Egawa J, Zhang Z, Almenar-Queralt A, Nguyen QM, Lajevardi Y, Kim K, Posadas E, Jeste DV, Roth DM, Patel PM, Patel HH, Head BP. Caveolin-1 regulation of disrupted-in-schizophrenia-1 as a potential therapeutic target for schizophrenia. J Neurophys. 117: 436-444, 2017.
  44. Liu X, Wong SS, Taype CA, Kim J, Shentu TP, Espinoza CR, Finley JC, Bradley JE, Head BP, Patel HH, Mah EJ, Hagood JS. Thy-1 interaction with Fas in lipid rafts regulates fibroblast apoptosis and lung injury resolution. Lab Invest. 97: 256-267, 2017.
  45. Egawa J, Schilling JM, Cui W, Posadas E, Sawada A, Alas B, Zemljic-Harpf AE, Fannon-Pavlich MJ, Mandyam CD, Roth DM, Patel HH, Patel PM, Head BP. Neuron-specific Caveolin-1 overexpression improves motor function and preserves memory in mice subjected to brain trauma. FASEB J. 31(8): 3403-3411, 2017.
  46. Schilling JM, Kassan A, Mandyam CD, Pearn ML, Voong A, Grogman G, Risbrough V, Niesman IR, Patel HH, Patel PM, Head BP. Inhibition of p75 neurotrophin receptor does not rescue cognitive impairment in adulthood after isoflurane exposure in neonatal mice. British Journal of Anaesthesia. 119: 465-471, 2017.
  47. Egawa J, Zemljic-Harpf AE, Mandyam CD, Niesman IR, Lysenko LV, Kleschevnikov AM, Roth DM, Patel HH, Patel PM, Head BP. Neuron-targeted caveolin-1 promotes ultrastructural and functional hippocampal synaptic plasticity. Cerebral Cortex, 1-12, 2017.
  48. Shahidi B, Shah SB, Esparza M, Head BP*, Ward S*. Skeletal muscle atrophy and degeneration in a mouse model of traumatic brain injury. J Neurotrauma 2018 [Epub ahead of print] *Co-senior author.
  49. Wang L, Grace Jang G, Ban DK, Sant V, Seth J, Kazmi S, Patel N, Yang Q, Lee J, Janetanakit W, Wang S, Head BP, Glinsky G, Lal R. Multifunctional stimuli responsive polymer-gated iron and gold-embedded silica nano golf balls: Nanoshuttles for targeted on-demand theranostics. Bone Research. 5: 17051, 2017.
  50. Pearn ML, Schilling JM, Jian M, Egawa J, Wu C, Mandyam C, Fannon-Pavlich MJ, Nguyen U, Bertoglio J, Kodama M, Mahata S, DerMardirossian C, Lemkuil BP, Han R, Mobley WC, Patel HH, Piyush PM, Head BP. RhoA inhibition prevents propofol-mediated growth cone collapse, axonal transport impairments, loss of synaptic connectivity, and behavioral deficits. British Journal of Anaesthesia, 2018.
  51. Schilling JM, Head BP, Patel HH. Caveolins as regulators of stress adaptation. Mol Pharm, 2018.
  52. Takashima Y, Fannon MJ, Galinato MH, Steiner NL, An M, Zemljic-Harpf AE, Somkuwar SS, Head BP, Mandyam CD. Neuroadaptations in the dentate gyrus following contextual cued reinstatement of methamphetamine seeking. Brain Struct Funct. 2018.
  53. Wang S, Head BP. Caveolin-1 in stroke neuropathology and neuroprotection: a novel molecular therapeutic target for ischemic-related injury. Curr. Vasc. Pharmacol. 2018.
  54. Eisinger KR, Gross KS, Head BP, Mermelstein PG. Interactions between strong receptors and metabotropic glutamate receptors and their impact on drug addiction in females. Horm Behav. 2018.

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