Symposium 15
3月27日［土］14:15-15:45
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Novel Therapeutic Strategy of Pulmonary Hypertension -From Bench to Bedside-
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第６回肺高血圧ワールドシンポジウムの病型分類／治療ガイドラインに基づき、肺高血圧症の理解は飛躍的に広がっている。エビデンスのある多くの肺血管拡張薬の使用が広がるとともに、早期発見・早期治療介入により肺動脈性肺高血圧症の生命予後は著しく改善している。しかしながら、肺高血圧症の病因は多岐にわたるとともに、その発症にはさまざまな要因が関わっているため、三系統の肺血管拡張薬の治療効果は必ずしも一定ではなく、期待される改善効果が得られない症例も少なくない。さらなる予後改善を目指すためにも、肺動脈性肺高血圧症の病態に応じた治療法を選択することが必要であり、発症機序に基づく個別化医療の実現を目指す必要がある。本シンポジウムでは肺高血圧症の発症機序および病態について理解を深めるとともに、トランスレーショナル研究成果に基づいた新たな治療法の可能性について総合的に議論したい。
Understanding of pulmonary hypertension has expanded dramatically in Japan, based on the guidelines of the 6th World Symposium on Pulmonary Hypertension. The use of various evidence-bearing pulmonary vasodilators and early detection and therapeutic interventions have significantly improved the prognosis of the patients with pulmonary arterial hypertension (PAH). However, since the etiology of pulmonary hypertension is diverse and various factors are involved in the development and progression of the disease, the treatment outcome of PAH specific medication is still not always sufficient.
It is necessary to proceed with personalized medicine on the basis of the pathogenesis of PAH to achieve maximum treatment efficacy. In this symposium, we would like to deepen our understanding of the underlying mechanism for the development of pulmonary hypertension, and comprehensively discuss future therapeutic targets based on the results of translational research.
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Keiko Takihara
Health and Counseling Center, Osaka University, Toyonaka
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Marc Humbert
Department of Respiratory and Intensive Care Medicine, University Paris-Saclay, Le Kremlin-Bicetre, France
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Marc Humbert
Department of Respiratory and Intensive Care Medicine, University Paris-Saclay, Le Kremlin-Bicetre, France
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Kohtaro Abe
Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka
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Kimio Satoh
Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Sendai
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Koichiro Kuwahara
Department of Cardiovascular Medicine, Shinshu University Graduate School of Medicine, Matsumoto
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Yuichi Tamura
Department of Cardiology, International University of Health and Welfare School of Medicine, Narita
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